PREVENTIVNA MEDICINSKA EPIGENETIKA

Milan Obrenović; Ivana Kavečan; Boris Privrodski; Tatjana Redžek Mudrinić

doi:10.46793/PP170623001O

Autori

Milan Obrenović Kabinet za molekularnu genetiku, Institut za zdravstvenu zaštitu dece i omladine Vojvodine, Novi Sad, Srbia
Ivana Kavečan Medicinski fakultet, Univerzitet u Novom Sadu, Odeljenje za medicinsku genetiku, Institut za zdravstvenu zaštitu dece i omladine Vojvodine, Novi Sad; Novi Sad
Boris Privrodski Klinika za dečiju hirurgiju, Institut za zdravstvenu zaštitu dece i omladine Vojvodine, Novi Sad; Novi Sad, Srbija
Tatjana Redžek Mudrinić Medicinski fakultet, Univerzitet u Novom Sadu, Odeljenje epileptologije, Institut za zdravstvenu zaštitu dece i omladine Vojvodine, Novi Sad; Novi Sad, Srbija

DOI:

https://doi.org/10.46793/PP170623001O

Ključne reči:

epigenetika, gojaznost, kardiovaskularna oboljenja, preventivna pedijatrija

Apstrakt

Epigenetika je oblast medicine koja se intenzivno razvija i saznanja iz ove oblasti se primenjuju u preventivnoj pedijatriji i drugim oblastima medicine. Primena epigenetičkih saznanja u preventivnoj pedijatriji je sve zastupljenija i interesantna sa više aspekata. U određenim okolnostima, s jedne strane uticaj epigenetičkih faktora može da izmeni ekspresiju gena i da dovede do ispoljavanja bolesti, a može svojim uticajem da deluje i preventivno, i da odloži ispoljavanje bolesti, poboljša kvalitet života i utiče na produženje života. Izmenom epigenetičkih faktora može se uticati na to da se pojava oboljenja odloži ili ne ispolji. Kako su epigenetičke promene reverzibilne, i nema primarnog oštećenja DNK sekvence niti promena na hromozomima, postoje velike mogućnosti za osmišljavanje strategije intervencije promenama životnog stila i samim tim primenama tzv. epigenetičke preventivne terapije.

Reference

Inbar-Feigenberg M, Choufani S, Butcher DT, Roifman M, Weksberg R. Basic concepts of epigenetics. Fertil Steril. 2013 Mar 1;99(3):607-15. doi: 10.1016/j.fertnstert. 2013. 01. 117. PMID:23357459.

Wright R, Saul RA. Epigenetics and primary care. Pediatrics. 2013 Dec;132(Suppl 3):S216-23. doi: 10.1542/peds.2013-1032F. PMID: 24298130.

Duarte JD. Epigenetics primer: why the clinician should care about epigenetics. Pharmacotherapy.2013;33(12):1362-8. doi: 10.1002/phar.1325. PMID: 23864439.

Lim JP, Brunet A. Bridging the transgenerational gap with epigenetic memory. Trends in Genetics 2013;29(3): 176-186. doi: 10.1016/j.tig.2012.12.008. PMID: 23410786.

Yehuda R, Daskalakis NP, Lehrner A, Desarnaud F, Bader HN, Makotkine I, Flory JD, Bierer LM, Meaney MJ. Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in Holocaust survivor offspring. Am J Psychiatry 2014;171(8):872-80. doi: 10.1176/appi.ajp.2014.13121571. PMID: 24832930

Attig L, Gabory A, Junien C. Early nutrition and epigenetic programming: chasing shadows. Curr Opin Clin Nutr Metab Care 2010;13(3):284-93. doi: 10.1097/MCO. 0b013e328338aa61. PMID: 20375884.

Cao-Lei L, De Rooij SR, King S, Matthews SG, Metz GAS, Roseboom TJ, Szyf M.Prenatal Stress and Epigenetics. Neurosci Biobehav Rev 2017; S0149-7634(16)30726-6. DOI: 10.1016/j.neubiorev.2017.05.016. PMID:28528960.

Girchenko P, Lahti J, Czamara D, Knight AK, Jones MJ, Suarez A, Hämäläinen E, Kajantie E, Laivuori H, Villa PM, Reynolds RM, Kobor MS, Smith AK, Binder EB, Räikkönen K. Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth. Clin Epigenetics 2017; 9:49. doi: 10.1186/s13148-017-0349-z. PMID: 28503212.

Choi SW, Claycombe KJ, Martinez JA, Friso S, Schalinske KL. Nutritional Epigenomics: A Portal to Disease Prevention. Adv Nutr 2013;4(5):530–532. doi: 10.3945/an.113.004168. PMCID: PMC4311512.

Contu L, Hawkes CA. A Review of the Impact of Maternal Obesity on the Cognitive Function and Mental Health of the Offspring. Int J Mol Sci. 2017;19(5). doi: 10.3390/ijms18051093. PMID: 28534818.

Thaler L, Steiger H. Eating Disorders and Epigenetics. Adv Exp Med Biol 2017;978:93-103. doi: 10.1007/978-3-319-53889-1_5. PMID:28523542.

Milagro FI, Mansego ML, De Miguel C, Martinez JA. Dietary factors, epigenetic modifications and obesity outcomes: progresses and perspectives Mol Aspects Med 2013;34(4):782-812. doi: 10.1016/j.mam.2012.06.010 PMID: 22771541

Bays H, Scinta W. Adiposopathy and epigenetics: an introduction to obesity as a transgenerational disease. Current Medical Research and Opinion 2015; 31(11): 2059-69. doi: 10.1185/03007995.2015.1087983. PMID:26331354.

Monte E, Fischer MA, Vondriska TM. Epigenomic Disruption of Cardiovascular Care: What It Will Take. Circ Res 2017;26;120(11):1692-1693. DOI: 10.1161/CIRCRESAHA.117.311072. PMID:28546346.

Kurotsu S, Suzuki T, Ieda M. Direct Reprogramming, Epigenetics, and Cardiac Regeneration. J Card Fail 2017; S1071-9164(17)30147-1. doi: 10.1016/j.cardfail.2017.05.009. PMID:28529134.

Kinnaird A. Michelakis D. Metabolic modulation of cancer: a new frontier with great translational potential. J Mol Med 2015;93(2):127–142. doi:10.1007/s00109-014-1250-2. PMID:25586106

López-León M, Goya RG. The Emerging View of Aging as a Reversible Epigenetic Process. Gerontology 2017. doi: 10.1159/000477209. PMID: 28538216.

Bartlett AA, Singh R, Hunter RG. Anxiety and Epigenetics. Adv Exp Med Biol 2017;978:145-166. doi: 10.1007/978-3-319-53889-1_8. PMID:28523545.

Holder LB, Haque MM, Skinner MK. Machine Learning for Epigenetics and Future Medical Applications. Epigenetics. 2017. doi: 10.1080/15592294.2017.1329068. PMID:28524769.

D’Urso A, Brickner JH. Mechanisms of epigenetic memory. Trends Genet. 2014 Jun; 30(6): 230–236. doi: 10.1016/j.tig.2014.04.004. PMID:24780085.