POVEZANOST UHRANJENOSTI, DISLIPIDEMIJE I JUTARNJE GLIKEMIJE KOD DECE ŠKOLSKOG UZRASTA U KRUPI NA UNI, BOSNA I HERCEGOVINA
Ključne reči:
dete, gojaznost, glukoza u krvi, dijagnoza, hronične nezarazne bolestiApstrakt
Uvod. Gojaznost je hronična multifaktorska bolest koja ima značajan uticaj na zdravlje i kvalitet života dece.
Cilj rada. Studija je imala za cilj da utvrdi učestalost prekomerne težine i gojaznosti kod dece školskog uzrasta u Krupi na Uni, Bosna i Hercegovina, kao i prisustvo dislipidemije i dijabetesa kod gojaznih učesnika.
Metod. Urađena je epidemiološka studija preseka, uključujući 40 (47,1%) devojčica i 45 (52,9%) dečaka. Ispitanicima je uzeta anamneza, pregledana je medicinska dokumentacija i sprovedeni su laboratorijski testovi koji su uključivali glikemiju natašte, ukupan holesterol i trigliceride u krvi. Rezultati. Normalna uhranjenost utvrđena je kod 54 (63,5%), neuhranjenost kod 12 (14,1%), prekomerna težina kod 5 (5,9%), a gojaznost kod 14 (16,5%) dece školskog uzrasta. Starost (p=0,477) i pol (p=0,435) nisu statistički značajno uticali na telesnu masu. Značajan broj dece školskog uzrasta imao je povišene vrednosti glukoze u krvi (predijabetes 28,2%, dijabetes 2,4%). Većina (96,4%) ispitanika imala je normalan nivo holesterola u krvi. Gojaznost je bila značajan prediktor povišenih vrednosti triglicerida u krvi (p=0,002), a niie uticala na vrednosti glukoze (p=0,726) i holesterola (p=0,749). Prekomerna težina i gojaznost pronađeni su kod više od petine dece školskog uzrasta. Povišene vrednosti triglicerida bili su pretežno prisutni kod gojazne dece školskog uzrasta. Gojaznost nije značajno uticala na vrednosti glukoze i holesterola u krvi. Dijabetes je utvrđen kod gojazne dece sa pozitivnom porodičnom anamnezom.
Zaključak. Gojaznost kao faktor rizika za nastanak hroničnih nezaraznih bolesti je neopravdano zanemarena kod dece školskog uzrasta.
Reference
Bralic I. An obese child in everyday pediatric practice. Paediatria Croatica. 2014; 58: Supplement; 233-237.
Yanovski JA. Pediatric obesity. An introduction. Appetite.2015;93:3-12. doi: 10.1016/j.appet.2015.03.028
Valerio G, Maffeis C, Saggese G, et al. Diagnosis, treatment and prevention of pediatric obesity: consensus position statement of the Italian Society for Pediatric Endocrinology and Diabetology and the Italian Society of Pediatrics. Ital J Pediatr. 2018;44(1):88. doi:10.1186/s13052-018-0525-6
Purnell JQ. Definitions, Classification, and Epidemiology of Obesity. [Updated 2018 Apr 12]. In: Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK279167/
Lakshman R, Elks CE, Ong KK. Childhood obesity. Circulation. 2012;126(14):1770-1779. doi:10.1161/CIRCULATIONAHA.111.047738
Romanelli R, Cecchi N, Carbone MG, et al. Pediatric obesity: prevention is better than care. Ital J Pediatr. 2020;46(1):103. doi:10.1186/s13052-020-00868-7
Wang Y, Lim H. The global childhood obesity epidemic and the association between socio-economic status and childhood obesity. Int Rev Psychiatry. 2012;24(3):176-188. doi:10.3109/09540261.2012.688195
Nittari, G, Scuri, S, Sagaro, G. G, Petrelli, F, Grappasonni, I. Epidemiology of Obesity in Children and Adolescents. In: Firstenberg, M.S, Stawicki, S.P, editors. Teamwork in Healthcare [Internet]. London: IntechOpen; 2020.
World Obesity Federation. 2019. Atlas of Childhood Obesity.
Shah B, Tombeau Cost K, Fuller A, Birken CS, Anderson LN. Sex and gender differences in childhood obesity: contributing to the research agenda. BMJ Nutr Prev Health. 2020;3(2):387-390. doi:10.1136/bmjnph-2020-000074
Bridger T. Childhood obesity and cardiovascular disease. Paediatr Child Health. 2009;14(3):177-182. doi:10.1093/pch/14.3.177
Hannon TS, Rao G, Arslanian SA. Childhood obesity and type 2 diabetes mellitus. Pediatrics. 2005;116(2):473-480. doi:10.1542/peds.2004-2536
Verbeeten KC, Elks CE, Daneman D, Ong KK. Association between childhood obesity and subsequent Type 1 diabetes: a systematic review and meta-analysis. Diabet Med. 2011;28(1):10-18. doi:10.1111/j.1464-5491.2010. 03160.x
Evertsen J, Alemzadeh R, Wang X. Increasing incidence of pediatric type 1 diabetes mellitus in Southeastern Wisconsin: relationship with body weight at diagnosis. PLoS One. 2009;4(9): e6873. doi: 10.1371/journal.pone.0006873
NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet. 2017;390(10113):2627-2642. doi:10.1016/S0140-6736(17)32129-3
Feingold KR. Obesity and Dyslipidemia. 2000. In: Feingold KR, Anawalt B, Boyce A, et al., editors Endotext [Internet]. South Dartmouth (MA). MDText.com, Inc.
Tall AR. Functions of cholesterol ester transfer protein and relationship to coronary artery disease risk. J Clin Lipidol. 2010;4(5):389-393. doi: 10.1016/j.jacl.2010.08.006
Lartey, A., Marquis, G.S., Aryeetey, R. et al. Lipid profile and dyslipidemia among school-age children in urban Ghana. BMC Public Health . 2018; 18, 320. https://doi.org/10.1186/s12889-018-5196-0
Centers for Disease Control and Prevention (CDC). Prevalence of abnormal lipid levels among youths --- United States, 1999-2006 [published correction appears in MMWR Morb Mortal Wkly Rep. 2010 Jan 29;59(3):78]. MMWR Morb Mortal Wkly Rep. 2010;59(2):29-33.
De Henauw S, Michels N, Vyncke K, et al. Blood lipids among young children in Europe: results from the European IDEFICS study. Int J Obes. 2014;38 Suppl 2: S67-S75. doi:10.1038/ijo.2014.137
Elmaoğulları S, Tepe D, Uçaktürk SA, Karaca Kara F, Demirel F. Prevalence of Dyslipidemia and Associated Factors in Obese Children and Adolescents. J Clin Res Pediatr Endocrinol. 2015;7(3):228-234. doi:10.4274/jcrpe.1867
Ghergerehchi R. Dyslipidemia in Iranian overweight and obese children. The Clin Risk Manag. 2009; 5:739-743. doi:10.2147/tcrm. s6388
Freedman DS, Dietz WH, Srinivasan SR, Berenson GS. The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa Heart Study. Paediatrics. 1999;103(6 Pt 1):1175-1182. doi:10.1542/peds.103.6.1175
Habib A, Molayemat M, Habib A. Association of lipid profile and BMI Z-score in southern Iranian children and adolescents. J Pediatr Endocrinol Metab. 2019;32(8):827-835. doi:10.1515/jpem-2019-0002
Nielsen TRH, Lausten-Thomsen U, Fonvig CE, et al. Dyslipidemia and reference values for fasting plasma lipid concentrations in Danish/North-European White children and adolescents. BMC Pediatr. 2017;17(1):116. Published 2017 Apr 28. doi:10.1186/s12887-017-0868-y
Gong CD, Wu QL, Chen Z, Zhang D, Zhao ZY, Peng YM. Glycolipid metabolic status of overweight/obese adolescents aged 9- to 15-year-old and the BMI-SDS/BMI cut-off value of predicting dyslipidemiain boys, Shanghai, China: a cross-sectional study. Lipids Health Dis. 2013; 12:129. doi:10.1186/1476-511X-12-129
Hanh NTH, Tuyet LT, Dao DTA, Tao Y, Chu DT. Childhood Obesity Is a High-risk Factor for Hypertriglyceridemia: A Case-control Study in Vietnam. Osong Public Health Res Perspect. 2017;8(2):138-146. doi: 10.24171/j.phrp.2017.8.2.06
Rinaldi AEM, de Oliveira, EP, Moreto F, Costa Pinto GF, Eduardo Corrente GJ, Burini RC. Dietary intake and blood lipid profile in overweight and obese schoolchildren. BMC Res Notes. 2012; 5: 598.
Lartey A, Marquis GS, Aryeetey R, Nti H. Lipid profile and dyslipidemia among school-age children in urban Ghana. BMC Public Health. 2018;18(1):320. doi:10.1186/s12889-018-5196-0
D'Adamo E, Guardamagna O, Chiarelli F, et al. Atherogenic dyslipidemia and cardiovascular risk factors in obese children. Int J Endocrinol. 2015; 2015:912047. doi:10.1155/2015/912047
Hagman E, Reinehr T, Kowalski J, Ekbom A, Marcus C, Holl RW. Impaired fasting glucose prevalence in two nationwide cohorts of obese children and adolescents. Int J Obes (Lond). 2014;38(1):40-45.
Hagman E, Arani PI, Fischer M, et al. Blood sugar levels are higher in obese young children in Sweden than in Poland. Acta Paediatr. 2014;103(11):1174-1178. doi:10.1111/apa.12760
Koutny F, Weghuber D, Bollow E, et al. Prevalence of prediabetes and type 2 diabetes in children with obesity and increased transaminases in European German-speaking countries. Analysis of the APV initiative. Pediatr Obes. 2020;15(4): e12601. doi:10.1111/ijpo.12601
Assunção SNF, Boa Sorte NCA, Alves CAD, Mendes PSA, Alves CRB, Silva LR. Glucose alteration and insulin resistance in asymptomatic obese children and adolescents. J Pediatr (Rio J). 2018;94(3):268-272. doi: 10.1016/j.jped.2017.06.008
Marcano M, Solano L, Pontiles M. Prevalencia de hiperlipidemia e hiperglicemia en niños obesos: riesgo aumentado de enfermedad cardiovascular? [Hyperlipidemia and hyperglycemia prevalence in obese children: increased risk of cardiovascular disease?]. Nutr Hosp. 2006;21(4):474-483.
Viner RM, Segal TY, Lichtarowicz-Krynska E, Hindmarsh P. Prevalence of the insulin resistance syndrome in obesity. Arch Dis Child. 2005;90(1):10-14. doi:10.1136/adc.2003.036467
Sinha R, Fisch G, Teague B, et al. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med. 2002;346(11):802-810. doi:10.1056/NEJMoa012578
Lee HS, Park HK, Hwang JS. HbA1c and glucose intolerance in obese children and adolescents. Diabet Med. 2012;29(7):e102-e105. doi:10.1111/j.1464-5491.2012. 03596.x
Koutny F, Weghuber D, Bollow E, et al. Prevalence of prediabetes and type 2 diabetes in children with obesity and increased transaminases in European German-speaking countries. Analysis of the APV initiative. Pediatr Obes. 2020;15(4): e12601. doi:10.1111/ijpo.12601
Reinehr T, Andler W, Kapellen T, et al. Clinical characteristics of type 2 diabetes mellitus in overweight European caucasian adolescents. Exp Clin Endocrinol Diabetes. 2005;113(3):167-170. doi:10.1055/s-2005-837522
Kelly LA, Lane CJ, Weigensberg MJ, et al. Parental history and risk of type 2 diabetes in overweight Latino adolescents: a longitudinal analysis. Diabetes Care. 2007;30(10):2700-2705. doi:10.2337/dc07-0050
