LEUKEMOIDNA REAKCIJA KAO POSLEDICA INFEKCIJE EPSTEIN-BARR VIRUSOM
DOI:
https://doi.org/10.46793/PP250131017SKljučne reči:
Leukemoidna reakcija, Epstein-Barr virus, infektivna mononukleozaApstrakt
Uvod: Leukemoidna rekacija je povećanje broja leukocita preko 30.000/µL sa povećanjem mladih ćelija, karakteristična za infektivne i maligne bolesti. Epstein-Barr virus je karakterističan po svom citopatogenom efektu na B limfocite. Uzročnik je infektivne mononukleoze i dovodi se u vezu sa nastankom Hočkinove bolesti, Non Hočkinovog limfoma i nazofaringealnog karcinoma. Nije česta pojava da infekcija Epstein-Barr virusom izazove povišen broj leukocita, što zahteva detaljnu dijagnostiku kako bi se diferencirala infektivna mononukleoza od leukemije.
Prikaz slučaja: U radu je prikazan slučaj obolele trogodišnje devojčice koja je od tegoba imala povišenu telesnu temperaturu 38.5°C koja je trajala tri dana pre nego što je urađena analiza krvne slike u kojoj se detektuju leukociti od 53.000/µL sa dominacijom limfocita i monocita. Nakon pregleda pedijatra utvrđuje se i obostrano povećanje limfnih čvorova vrata do 1 cm u prečniku. Ostali nalaz po sistemima uredan. U bolničkim uslovima urađen periferni razmaz krvi, punkcija koštane srži, kao i serologija na Epstein-Barr virus, te je zaključeno da se radi o infektivnoj mononukleozi.
Zaključak: Iako je retka pojava visokog broja leukocita usled Epstein-Barr virusa, uvek treba isključiti leukemiju, naročito ako su ostali fizikalni nalazi oskudni.
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