AZOT MONOKSID U IZDAHNUTOM VAZDUHU I ALERGIJSKA SENZIBILIZACIJA KOD DECE SA ASTMOM
DOI:
https://doi.org/10.46793/PP151107009ZKljučne reči:
astma, deca, azot monoksid, senzibilizacijaApstrakt
Uvod: Cilj našeg ispitivanja je bio merenje azot monokisida u izdahnutom vazduhu (FeNO) kod dece sa astmom i korelacija sa stepenom senzibilizacije na aeroalergene.
Metodologija: U ispitivanje je uključeno 52 dece (uzrast od 12.40 ± 2.35 godina), 28 dečaka (53.85%) i 24 devojčica (46.15%). Prosečna dužina trajanja astme je bila 8.33 ± 3.93 godina.Stepen senzibilizacije na aeroalergene određivan je kožnim testom i procenjivan atopijskim indeksom (AI).
Rezultati: Prosečna vrednost FeNO kod dece sa stabilnom alergijskom astmom je bio 43.92 ± 35.63 ppb, a nakon 4 nedelje anitinflamatorne terapije, vrednost FeNO se smanjila na 34.92 ± 32.04 ppb (p<0.05). U odnosu na AI, vrednosti FeNO su bile 41.00 vs. 40.69 vs 50.88 ppb, bez statisičke značajnosti. Najviša vrednost FeNO izmerena je kod dece sa polisenzibilizacijom, 56.85 ppb (Me 48.50), dok su kod dece senzibilisane samo na sezonske alergene vrednosti FeNO bile 15.29 ppb (Me 12) i kod dece senzibilisane na alergene unutrašnje sredine FeNO vrednosti su bile 32.22 ppb (Me 26). Alergijski rinitis, dužina trajanja astme i pol ispitanika nisu bili značajno povezani sa izmerenim vrednostima FeNO. Značajna negativna korelacija je utvrđena između indeksa telesne mase (BMI) i FeNO, r = -0,43 (p˂0.01).
Zakljucak: Deca koja boluju od alergijske astme imaju povišene vrednosti FeNO, što je koristan indikator odgovora na antiinflamatornu terapiju.
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