PLUĆNO KRVARENJE U NOVOROĐENČETA I MOGUĆNOSTI PREVENCIJE
DOI:
https://doi.org/10.46793/PP151008003VKljučne reči:
plućno krvarenje, novorođenče, faktori rizika, prevencijaApstrakt
Plućno krvarenje predstavlja teško akutno pogoršanje koje ima visoku stopu neonatalnog mortaliteta i morbiditeta. Nekoliko faktora rizika koji dovode do plućnog krvarenja je identifikovano ali tačna patogeneza nije poznata. Značajnu ulogu u nastanku plućnog krvarenja u neonatologiji ima razvoj plućnog edema koji obično nastaje usled povećanog plućnog protoka. Hemodinamski značajni duktus arteriozus, prematuritet, intrauterusni zastoj rasta i primena plućnog surfaktanta značajno doprinose povećanoj incidenci plućnog krvarenja. Specifična terapija ne postoji. U ovom članku posebna pažnja je posvećena identifikaciji faktora rizika i aktuelnim stavovima o tretmanu kao mogućnostima za prevenciju plućnog krvarenja kod novorođenčeta.
Reference
Berger TM, Allred EN, Van Marter LJ. Antecedents of clinically significant pulmonary hemorrhage among newborn infants. J Perinatology. 2000;20(5):295-300
Cole VA, Normand IC, Reynolds EO, Rivers RP. Pathogenesis of hemorrhagic pulmonary edema and massive pulmonary hemorrhage in the newborn. Paediatrics. 1973;
Evans N, Kluckow M. High pulmonary blood flow and pulmonary hemorrhage. Pediatr Res 1999; 45: 195a.
Greenough A, Milner AD. Pulmonary haemorrhage. In: Rennie JM, ed. Roberton’s textbook of neonatology, 4th edn. Edinburgh: Churchill Livingstone, 2005, p. 512–5.
Clyman RI, Chan CY, Mauray F, Chen YQ, Cox W, Seidner SR, Lord EM, Weiss H, Waleh N, Evans SM, Koch CJ. Permanent anatomic closure of the ductus arteriosus in newborn baboons: the roles of postnatal constriction, hypoxia, and gestation. Pediatr Res. 1999 Jan; 45(1):19-29.
Nick Evans. Patent ductus arteriosus in the neonate. Current Paediatrics (2005) 15, 381-389.
Evans N, Iyer P. Incompetance of the foramen ovale in preterm infant requring ventilation. J Pediatr 1994; 125:786-92.
Evans N, Iyer P. Assesment of ductus aretriousus shunting in preterm infants requiring ventilation: effect of iner-atrial shunting. J Pediatr 1994; 125:778-785.
Evans N., Kluckow M. Ductal shunting, high pulmonary blood floow, and pulmonary hemorrhage. J Pediatr 2000; 137:68-72.
Raju TN, Langenberg P. Pulmonary hemorrhage and exogenous surfactant therapy: a meta-analysis. J Pedatr 1993; 123:603-610.
Kaapa P, Seppanen M, Kero P, Saraste M. Pulmonary hemodynamics after synthetic surfactant replacment in neonatal respiratory distress syndrome. J Pediatr 1993; 123:115-9.
AlKharfy ТМ. High-Frequency Ventilation in the Management of Very-Low-Birth-Weight Infants with Pulmonary Hemorrhage AmJPerinatol. 2004; 21(1):19-26
Pandit PB, Dunn MS, Colucci EA. Surfactant therapy in neonates with respiratory deterioration due to pulmonary hemorrhage. Paediatrics. 1995;95(1):32-36.
Olomu N, Kulkarni R, Manco - Johnson M, Treatment of Severe Pulmonary Hemorrhage With Activated Recombinant Factor VII (rFVIIa) in Very Low Birth Weight Infant. J perinatology. 2002;22(8):672-674.
Cetin H, Yalaz M, Akisu M, Karapinar DY, Kvakli K, Kultursay N. The use of recombinant activated factor VII in the treatment of massive pulmonary hemorrhage in a preterm infant. Blood Coagul Fibrinolysis. 2006;17(3):213-216.
Prof Nick Evans. Practical Guideline to PDA Treatment at RPA Hospital. 2013;Tomaszewska M, Stork E, Minich NM, Friedman H, Berlin S, Hack. Pulmonary hemorrhage: clinical course and outcomes among very low-birth-weight infants. Arch Pediatr Adolesc Med. 1999; 153(7):715-721.
