OKSIDATIVNI STRES KOD GOJAZNE DECE-KAKO GA SPREČITI ILI SMANJITI?
DOI:
https://doi.org/10.46793/PP170205004KKljučne reči:
antioksidansi, fizička aktivnost, gojaznost, inflamacija, oksidativni stresApstrakt
Hipertofično masno tkivo je značajan izvor reaktivnih vrsta kiseonika (RVK) koji dovode do povećanja ekspresije adipokina i infiltracije inflamatornih ćelija. Ovi poslednji dalje sekretuju nove RVK čineći tako povratnu spregu između oksidativnog stresa i inflamacije u masnom tkivu, sa posledičnim promenama u signalnim putevima i brojnim poremećajima kao što su metabolički sindrom, diabetes mellitus tip 2, kardiovaskularne bolesti. Istraživanja pokazuju da promena životnih navika zasnovana na promeni načina ishrane, kao i povećana i redovna fizička aktivnost mogu dovesti do smanjenja oksidativnog stresa i inflamacije. Takođe, skorije studije pokazuju da suplementacija antioksidansima može popraviti antioksidantni status. U daljim redovima će biti reči o patofiziološkim mehanizmima gojaznošću indukovanog oksidativnog stresa kod dece i adolescenata, kao i strategiji u cilju smanjenja istog.
Reference
Murer SB, Aeberli I, Braegger CP, Gittermann M, Hersberger M, Leonard SW, et al. Antioxidant supplements reduced oxidative stress and stabilized liver function tests but did not reduce inflammation in a randomized controlled trial in obese children and adolescents. J Nutr. 2014;144(2):193-201.doi: 10.3945/jn.113.185561.
Biswas SK. Does the interdependence between oxidative stress and inflammation explain the antioxidant paradox? Oxid Med Cell Longev. 2016;2016:5698931. doi:10.1155/2016/5698931.
Matusik P, Prokopowicz Z, Norek B, Olszanecka-Glinianowicz M, Chudek J, Malecka-Tendera E. Oxidative/Antioxidative Status in Obese and Sport Trained Children: A Comparative Study. Biomed Res Int. 2015;2015:315747. doi: 10.1155/2015/315747.
Razzaghy-Azar M, Nourbakhsh M, Pourmoteabed A, Nourbakhsh M, Ilbeigi D, Khosravi M. An Evaluation of Acylated Ghrelin and Obestatin Levels in Childhood Obesity and Their Association with Insulin Resistance, Metabolic Syndrome, and Oxidative Stress. J Clin Med. 2016;5(7):E61. doi: 10.3390/jcm5070061.
Salmon AB. Beyond Diabetes: Does Obesity-Induced Oxidative Stress Drive the Aging Process? Antioxidants (Basel). 2016;5(3):E24. doi:10.3390/antiox5030024.
Klisic AN, Vasiljevic ND, Simic TP, Djukic TI, Maksimovic MZ, Matic MG. Association between C-reactive protein, anthropometric and lipid parameters among healthy normal weight and overweight postmenopausal women in Montenegro. Lab Med. 2014;45(1):12-16. PMID: 24719979.
Klisić A, Kotur-Stevuljević J, Kavarić N, Jovanović M, Škerović V. Correlation between fibrinogen level and cardiometabolic risk factors in overweight/obese postmenopausal women. Timočki medicinski glasnik. 2016;41(2):83-90.UDK 547.962.4-055.2.
Facchini FS, Hua NW, Reaven GM, Stoohs RA. Hyperinsulinemia: the missing link among oxidative stress and age-related diseases? Free Radic Biol Med. 2000;29(12):1302-1306.PMID: 11118820.
Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2004;114(12):1752-1761.doi: 10.1172/JCI21625.
Lee H, Lee YJ, Choi H, Ko EH, Kim JW. Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion. J Biol Chem. 2009;284(16):10601-10609. doi: 10.1074/jbc.M808742200.
Higuchi M, Dusting GJ, Peshavariya H, Jiang F, Hsiao ST, Chan, EC, et al. Differentiation of human adipose-derived stem cells into fat involves reactive oxygen species and forkhead box O1 mediated upregulation of antioxidant enzymes. Stem Cells Dev. 2013;22(6):878-888.doi: 10.1089/scd.2012.0306.
Horvath TL, Andrews ZB, Diano S. Fuel utilization by hypothalamic neurons: Roles for ROS. Trends Endocrinol Metab. 2009;20(2):78-87.doi: 10.1016/j.tem.2008.10.003.
Albuali WH. Evaluation of oxidant-antioxidant status in overweight and morbidly obese Saudi children. World J Clin Pediatr. 2014;3(1):6-13.doi: 10.5409/wjcp.v3.i1.6.
Correia-Costa L, Sousa T, Morato M, Cosme D, Afonso J, Areias JC, et al. Oxidative stress and nitric oxide are increased in obese children and correlate with cardiometabolic risk and renal function. Br J Nutr. 2016;116(5):805-815.doi: 10.1017/S0007114516002804.
Pou KM, Massaro JM, Hoffman U, Vasan RS, Maurovich-Horvat P, Larson MG, et al. Visceral and Subcutaneous Adipose Tissue Volumes are cross-sectionally related to Markers of Inflammation and Oxidative Stress: the Framingham Heart Study. Circulation. 2007;116(11):1234-1241.doi:10.1161/CIRCULATIONAHA.107.710509.
Crist BL, Alekel DL, Ritland LM, Hanson LN, Genschel U, Reddy MB. Association of Oxidative Stress, Iron, and Centralized Fat Mass in Healthy Postmenopausal Women. J Womens Health(Larchmt). 2009;18(6):795-801. doi: 10.1089/jwh.2008.0988.
D’Archivio M, Annuzzi G, Varì R, Filesi C, Giacco R, Scazzocchio B, et al. Predominant role of obesity/insulin resistance in oxidative stress development. Eur J Clin Invest. 2012;42(1):70-78. doi: 10.1111/j.1365-2362.2011.02558.x.
Dennis BA, Ergul A, Gower BA, Allison JD, Davis CL. Oxidative Stress and Cardiovascular Risk in Overweight Children in an Exercise Intervention Program. Child Obes. 2013;9(1):15-21. doi: 10.1089/chi.2011.0092.
Camargos ACR, Mendonça VA, Andrade CA, Oliveira KS, Tossige-Gomes R, Rocha-Vieira E, et al. Neuroendocrine Inflammatory Responses in Overweight/Obese Infants. PLoS ONE. 2016;11(12):e0167593.doi: 10.1371/journal.pone.0167593.
Klisic A, Kavaric N, Soldatovic I, Bjelakovic B, Kotur-Stevuljevic J. Relationship between cardiovascular risk score and traditional and nontraditional cardiometabolic parameters in obese adolescent girls. J Med Biochem. 2016;35(3):282-292. doi: 10.1515/jomb-2016-0005.
Vehapoglu A, Turkmen S, Goknar N, Özer ÖF. Reduced antioxidant capacity and increased subclinical inflammation markers in prepubescent obese children and their relationship with nutritional markers and metabolic parameters. Redox Rep. 2016;21(6):271-280. doi: 10.1080/13510002.2015.1133035.
Klisic A, Kotur-Stevuljevic J, Kavaric N, Martinovic M, Matic M. The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women. EAT WEIGHT DISORD - ST 2016; doi: 10.1007/s40519-016-0325-1.
Klisić A, Kotur-Stevuljević J, Kavarić N, Jovanović M. The influence of obesity on serum uric acid level in postmenopausal women. Timočki medicinski glasnik. 2016;41(1):20-26.UDK 613.25-055.2:616-074.
Rupérez AI, Gil A, Aguilera CM. Genetics of Oxidative Stress in Obesity. Int J Mol Sci. 2014;15(2):3118-3144. doi:10.3390/ijms15023118.
Olusi SO. Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotective enzymes in humans. Int J Obes Relat Metab Disord. 2002;26(9):1159–1164.doi: 10.1038/sj.ijo.0802066.
Ozata M, Mergen M, Oktenli C, Aydin A, Sanisoglu SY, Bolu E, et al. Increased oxidative stress and hypozincemia in male obesity. Clin Biochem. 2002;35(8):627-631.PMID: 12498997.
Sfar S, Boussoffara R, Sfar MT, Kerkeni A. Antioxidant enzymes activities in obese Tunisian children. Nutr J. 2013;12:18. doi: 10.1186/1475-2891-12-18.
Kobayasi R, Akamine EH, Davel AP, Rodrigues MA, Cavalho CR, Rossoni LV. Oxidative stress and inflammatory mediators contribute to endothelial dysfunction in high-fat diet-induced obesity in mice. J Hypertens. 2010;28(10):2111-2119. doi: 10.1097/HJH.0b013e32833ca68c.
Nakao C, Ookawara T, Sato Y, Kizaki T, Imazeki N, Matsubara O, et al. Extracellular superoxide dismutase in tissues from obese (ob/ob) mice. Free Radical Res. 2000;33(3):229-241. PMID: 10993477.
Brown LA, Kerr CJ, Whiting P, Finer N, McEneny J, Ashton T. Oxidant stress in healthy normal-weight, overweight, and obese individuals. Obesity (Silver Spring). 2009;17(3):460-466. doi: 10.1038/oby.2008.590.
Savini I, Catani MV, Evangelista D, Gasperi V, Avigliano L. Obesity-associated oxidative stress: strategies finalized to improve redox state. Int J Mol Sci.2013;14(5):10497-10538. doi: 10.3390/ijms140510497.
Stefanović A, Kotur-Stevuljević J, Spasić S, Bogavac-Stanojević N, Bujisić N. The influence of obesity on the oxidative stress status and the concentration of leptin in type 2 diabetes mellitus patients. Diabetes Res Clin Pract. 2008;79(1):156-163.doi: 10.1016/j.diabres.2007.07.019.
Ozgen IT, Tascilar ME, Bilir P, Boyraz M, Guncikan MN, Akay C, et al. Oxidative stress in obese children and its relation with insulin resistance. J Pediatr Endocrinol Metab. 2012;25(3-4):261-266.PMID: 22768654.
Klisic A, Gouri A, Skerovic V, Jovanovic M, Kavaric N. Retinol-binding protein 4 in obese and obese-diabetic postmenopausal women in Montenegro. J Health Sci. 2015;5(3):78-84.doi: 10.17532/jhsci.2016.290.
Reinehr T. Lifestyle intervention in childhood obesity: changes and challenges. Nat Rev Endocrinol. 2013;9(10):607-614.doi: 10.1038/nrendo.2013.149.
Huang C-J, McAllister MJ, Slusher AL, Webb HE, Mock JT, Acevedo EO. Obesity-Related Oxidative Stress: the Impact of Physical Activity and Diet Manipulation. Sports Med Open. 2015;1:32. doi:10.1186/s40798-015-0031-y.
Cakmak A, Zeyrek D, Atas A, Erel O. Paraoxonase activity in athletic adolescents. Pediatr Exerc Sci. 2010;22(1):93-104.PMID: 20332543.
Kelishadi R, Hashemi M, Mohammadifard N, Asgary S, Khavarian N. Association of changes in oxidative and proinflammatory states with changes in vascular function after a lifestyle modification trial among obese children. Clin Chem. 2008;54(1):147-153. doi: 10.1373/clinchem.2007.089953.
Holt EM, Steffen LM, Moran A, Basu S, Steinberger J, Ross JA, et al. Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents. J Am Diet Assoc. 2009;109(3):414–421.doi: 10.1016/j.jada.2008.11.036.
Kabasakalis A, Kalitsis K, Nikolaidis MG, Tsalis G, Kouretas D, Loupos D, et al. Redox, iron, and nutritional status of children during swimming training. J Sci Med Sport. 2009;12(6):691-696. doi: 10.1016/j.jsams.2008.05.005.
Zivkovic V, Lazarevic P, Djuric D, Cubrilo D, Macura M, Vuletic M, et al. Alteration in basal redox state of young male soccer players after a six-month training programme. Acta Physiol Hung. 2013;100(1):64-76.doi: 10.1556/APhysiol.100.2013.1.6.
Codoñer-Franch P, Valls-Bellés V, Arilla-Codoñer A, Alonso-Iglesias E. Oxidant mechanisms in childhood obesity: the link between inflammation and oxidative stress. Transl Res. 2011;158(6):369-384. doi: 10.1016/j.trsl.2011.08.004.
Puchau B, Ochoa MC, Zulet MA, Marti A, Martinez JA, Members G. Dietary total antioxidant capacity and obesity in children and adolescents. Int J Food Sci Nutr. 2010;61(7):713-721. doi: 10.3109/09637481003757860.
Ortega RM, Rodriguez-Rodriguez E, Aparicio A, Jimenez-Ortega AI, Palmeros C, Perea JM, et al. Young children with excess of weight show an impaired selenium status. Int J Vitam Nutr Res. 2012;82(2):121-129. doi: 10.1024/0300-9831/a000101.
Woo J, Shin KO, Yoo J-H, Park S, Kang S. The effects of detraining on blood adipokines and antioxidant enzyme in Korean overweight children. Eur J Pediatr. 2012;171(2):235-243.doi: 10.1007/s00431-011-1518-2.
Mielgo-Ayuso J, Valtueña J, Huybrechts I, Breidenassel C, Cuenca-García M, De Henauw S, et al. Fruit and vegetables consumption is associated with higher vitamin intake and blood vitamin status among European adolescents. Eur J Clin Nutr. 2017 Jan 25. doi:10.1038/ejcn.2016.232.
Devaraj S, Leonard S, Traber MG, Jialal I. Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome. Free Radic Biol Med. 2008;44(6):1203-1208.doi: 10.1016/j.freeradbiomed.2007.12.018.
Vincent HK, Bourguignon CM, Weltman AL, Vincent KR, Barrett E, Innes KE, et al. Effects of antioxidant supplementation on insulin sensitivity, endothelial adhesion molecules, and oxidative stress in normal-weight and overweight young adults. Metabolism. 2009;58(2):254-262.doi: 10.1016/j.metabol.2008.09.022.
Kelishadi R, Hashemipour M, Adeli K, Tavakoli N, Movahedian-Attar A, Shapouri J, et al. Effect of zinc supplementation on markers of insulin resistance, oxidative stress, and inflammation among prepubescent children with metabolic syndrome. Metab Syndr Relat Disord. 2010;8(6):505-510.doi: 10.1089/met.2010.0020.
D'Adamo E, Marcovecchio ML, Giannini C, de Giorgis T, Chiavaroli V, Chiarelli F, et al. Improved oxidative stress and cardio-metabolic status in obese prepubertal children with liver steatosis treated with lifestyle combined with Vitamin E. Free Radic Res. 2013;47(3):146-153.doi: 10.3109/10715762.2012.755262.
Nobili V, Manco M, Devito R, Ciampalini P, Piemonte F, Marcellini M. Effect of vitamin E on aminotransferase levels and insulin resistance in children with non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2006;24(11-12):1553-1561.doi: 10.1111/j.1365-2036.2006.03161.x.
Nobili V, Manco M, Devito R, Di Ciommo V, Comparcola D, Sartorelli MR, et al. Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: a randomized, controlled trial. Hepatology. 2008;48(1):119-128.doi: 10.1002/hep.22336.
