SAVREMENI PRISTUP PREVENCIJI I DIJAGNOZI KONGENITALNE TOKSOPLAZMOZE: ITALIJANSKO ISKUSTVO
DOI:
https://doi.org/10.46793/PP180307009SKljučne reči:
Toxoplasmosis, dijagnoza, IGRA tes, novorođenčad, trudnoćaApstrakt
Kongenitalna toksoplazmoza je ozbiljan uzrok morbiditeta i mortaliteta inficirane novorođenčadi, i čak i kada klasičan trijas nije prisutan: hidrocefalus, intrakranijalne kalcifikacije i horioretinitis, moguće je da se razvije retinalna bolest tokom detinjstva ili adolescencije. Preventivne strategije i pravilna dijagnoza kod trudnica i novorođenčadi je od velike važnosti. Infekcija najčešće protiče asimptomataski i dijagnoza se postavlja serološki. Kod trudnica diferencijalna dijagnoza izmedju rane serokonverzije i lažno pozitivnog IgM je uvek diskutabilna. Postavljanje dijagnoze na rođenju je komplikovano; odluka da se započne lečenje potencijalno štetnim agensima zasniva se prvenstveno na laboratorijskim nalazima (detekcija anti-Toxoplasma IgM i IgA, ili detekctijaperzistentne produkcije specifičnog IgG tokom prve godine života). Tumačenje nalaza je vrlo problematično, pošto su rezultati često heterogeni. U toku su istraživanja da se razvije test koji će ispitivati celularni imunitet uključen u infekciju kao što je interferon-gamma povezan sa Quantiferon ftestom za Mycobacterium tuberculosis.
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