SAVREMENA SHVATANJA ETIOPATOGENEZE MIOKARDITISA U DECE
DOI:
https://doi.org/10.46793/PP180228006BKljučne reči:
miokarditis, etiopatogeneza, decaApstrakt
Miokarditis tj. inflamacija tkiva miokarda predstavlja veoma kompleksan klinički entititet koji u mnogim svojim segmentima predstavlja enigmu za lekare i istraživače.
Pored virusa koji su u najvećem broju slučajeva glavni inicijatori inflamacije srca u dece, miokarditis može biti uzrokovan i toksinima, ishemijom, mehaničkim oštećenjem, lekovima, ali i imunim reakcijama kod transplantirane dece ili u sklopu sistemskih bolesti vezivnog tkiva. Iako je incidenca klinički manifestnih formi miokarditisa relativno mala, evolucija bolesti i često nepovoljan tok: razvoj dilatantne kardiomiopatije, kliničke slike aritmogene displazije desne komore ili infarkta miokarda i ne retko fulminantni tok bolesti, pridaju mu veliki sociomedicinski značaj. Iako je danas nedvosmisleno pokazano da je ključna komponenta koja određuje način i formu ispoljavanja bolesti kao i njen konačan ishod upravo kvalitet imunog odgovora, još uvek postoje velike dileme vezane za način kliničke evaluacije i terapiju kako dece tako i odraslih osoba sa miokarditisom.
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