VACCINATION IN PREGNANCY - CHALLENGES AND NOVELTIES

Authors

DOI:

https://doi.org/10.46793/PP260327014I

Keywords:

vaccination, pregnancy, newborn

Abstract

Vaccines are the most effective way to prevent infectious diseases. Immunization is a key compo-nent of primary healthcare. Maternal immunization before and/or during the pregnancy proves to significantly reduce maternal and infant morbidity and mortality associated with the diseases caused by pathogens that are relevant to the perinatal period and early life, and for which there are currently no other effective alternative preventive measures. Women can be vaccinated before or during the pregnancy to protect themselves and pass immunity directly to their babies.The mother's immune system in pregnancy plays a key role in the development of child’s immunity. Therefore it is important to explore this area that presents a challenge for deci-sion-making regarding how, when, and why vaccinate women in a reproductive period. 

References

https://www.who.int/news-room/fact-sheets/detail/immunization-coverage (last accessed 08.02.2026)

https://vaccineknowledge.ox.ac.uk/herd-immunity (last accesses 08.02.2026)

Psarris A, Sindos M, Daskalakis G, Chondrogianni ME, Panayiotou S, Antsaklis P, Loutradis D. Immunizations during pregnancy: How, when and why. Eur J Obstet Gynecol Reprod Biol. 2019;240:29-35. doi: 10.1016/j.ejogrb.2019.06.019

Kollmann TR, Marchant A, Way SS. Vaccination strategies to enhance immunity in neonates. Science. 2020;368(6491):612-615. doi: 10.1126/science.aaz9447

Morein B, Abusugra I, Blomqvist G. Immunity in neonates. Vet Immunol Immunopathol. 2002;87(3-4):207-213. doi: 10.1016/s0165-2427(02)00078-8

Lacković M, Mihajlović S, Bakić T, Marina Lj, Stefan Šojat A, Ilić A, Rovčanin M, F Mošković F, Filipović I. Imunski sistem u trudnoći. Prev Ped. 2020; 6(1-2): 37-40

Munoz FM, Jamieson DJ. Maternal Immunization. Obstet Gynecol. 2019;133(4):739-753. doi: 10.1097/AOG.0000000000003161

Pellegrini C, McCabe ER. Maternal immunization at the crossroads. Vaccine. 2015;33(47):6501-6502. doi: 10.1016/j.vaccine.2015.06.118

Álvarez Aldeán J, José Álvarez García F, de la Calle Fernández-Miranda M, Figueras Falcón T, Iofrío de Arce A, López Rojano M, Rivero Calle I, Suy Franch A. Vaccination in pregnancy. Consensus document of the CAV-AEP and the SEGO. An Pediatr (Engl Ed). 2024;100(4):268-274. doi: 10.1016/j.anpede.2024.02.014

Sealey KL, Belcher T, Preston A (2016) Bordetella pertussis epidemiology and evolution in the light of pertussis resurgence. Infect Genet Evol. 40:136–143.

Etti M, Calvert A, Galiza E, Lim S, Khalil A, Le Doare K, Heath PT. Maternal vaccination: a review of current evidence and recommendations. Am J Obstet Gynecol. 2022;226(4):459-474. doi: 10.1016/j.ajog.2021.10.041

Trifunović Kubat J, Sazdanović P, Mihajlović S, Filipović I, Mošković F. COVID19 kod trudnica. Prev Ped. 2022;8(1-2):8-11.

Filipović I, Živković Z, Zdjelar S, Ostojić O, Mihajlović S. Infekcija SARS CoV-2 u neonatalnom uzrastu. Prev Ped. 2022;8(1-2):12-15.

Munoz FM, Jamieson DJ. Maternal Immunization. Obstet Gynecol. 2019;133(4):739-753. doi: 10.1097/AOG.0000000000003161

Santilli V, Sgrulletti M, Costagliola G, Beni A, Mastrototaro MF, Montin D, Rizzo C, Martire B, Miraglia Del Giudice M, Moschese V; Italian Society of Pediatric Allergy and Immunology (SIAIP) Vaccine Committee. Maternal Immunization: Current Evidence, Progress, and Challenges. Vaccines (Basel). 2025;13(5):450. doi: 10.3390/vaccines13050450

Cairns A, Hogan J, Mackillop L. Vaccinations in pregnancy. Obstet Gynaecol Reprod Med. 2022;32(8):163-171. doi: 10.1016/j.ogrm.2022.05.001

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Published

04/18/2026

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Review Articles