SEVERITY OF BRONCHIOLITIS ASSOCIATED WITH ATYPICAL PATHOGENS IN HOSPITALIZED INFANTS IN GEORGIA
DOI:
https://doi.org/10.46793/PP151031010CKeywords:
mycoplasma pneumoniae, chlamydophila pneumoniae, respiratory syncytial virus, bronchiolitis, childrenAbstract
Introduction: Bronchiolitis is the most common reason for hospitalization worldwide. Respiratory syncytial virus (RSV), human Metapneumovirus, human Rhinoviruses, human Bocavirus have been shown to predominate. A few studies however have attempted to determine whether other pathogens, particularly Mycoplasma Pneumoniae (Mpn) and Chlamydophila pneumoniae (Cpn), are associated with bronchiolitis in children under 2 years of age. The aim of this study was to determine the prevalence and severity of Mpn and Cpn infection in children under the age of two years presenting to the Iashvili Central Children Hospital in Tbilisi.
Material and Methods: Acute and convalescent serum samples were tested by ELISA for IgM and IgG antibodies to RSV, Cpn and Mpn. 37 children under two years of age were studied. In 19 patients out of 37 (51.35%) etiological diagnosis were established and in 18 patients (48.65%) no pathogens were found. 11 patients (29.72%) had either Cpn or Mpn and 8 patients (21.62%) had RSV.
Results: Children infected with Cpn and Mpn had less severe bronchiolitis than those infected with RSV. There were no statistically significant differences between groups with respect to length of hospital stay.
Conclusion: Our study underlines the importance of atypical bacterial pathogens in acute bronchiolitis in children under two years of age and highlights the complex epidemiology and clinical features of these pathogens in this age group.
References
Nair H, Nokes DJ, Gessner BD. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet 2010; 375: 1545-55.
Qumar K, Skjerven HO, Mikalsen IB. Mikalsen IB. Acute bronchiolitis in infants, a review. Scand J Trauma Resusc Emerg Med. 2014 Apr 3; 22-23.
Ji W,Chen ZR,Zhou WF, Sun HM,Li BQ,Cai LH, et al. Etiology of acute respiratory tract infection in hospitalizedchildrenin Suzhou from 2005 to 2011.Zhonghua Yu Fang Yi Xue Za Zhi. 2013; Jun;47 (6):497-503.
Miller KE, Gebretsadik T, Carroll KN, Dupont WD, Mohamed YA, Morin LL, et al. Viral Etiologies of infant bronchiolitis, croup, and upper respiratory illness during four consecutive years. Pediatr Infect Dis J. 2013; Sep; 32(9): 950-5.
Kristj'ansson S, Loudrup C, Wennergren G, Strannegard I-L, Carlsen K-H.Nebulised racemic adrenaline in the treatment of acute bronchiolitis in infants and toddlers. Archives of Disease in Childhood 1993; Dec; 69 (6): 650-4.
