HUMAN PAPILOMA VIRUSES DETECTION IN ADOLESCENT WOMEN WITH ABNORMALN CYTOLOGY IN CROATIA
DOI:
https://doi.org/10.46793/PP170207011LKeywords:
Cervical intraepithelial neoplasia, Human papilloma viruses, AdolescentsAbstract
The association between certain human papillomaviruses (HPV) and cervical intraepithelial neoplasia (CIN) is well documented, but still unknown among Croatian adolescent women. Women between the age of 15 and 20 with cytomorphologically abnormal smears (CIN I-IV) were tested for the presence of HPV. Consensus and specific primers were used in the polymerase chain reaction (PCR to detect the most common types: 6, 11, 16, 18, 31 and 33. Beside low-risk HPV 6/11 (25.8%) the most frequently observed types were high-risk HPV types 16 (20.2%) and 31 (17.8%). Globally, the HPV positivity rate declines with age. The presence of HPV DNA significantly increased from 35.5 to 61.1% along with the severity of the cervical intraepithelial neoplasia (CIN I-IV). HPV type 6/11 was strong associated with CIN I (33.8%), HPV type 31 with CIN II (22.9%) and HPV type 16 with CIN III (50%).
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