NON – IgE – MEDIATED GASTROINTESTINAL FOOD ALLERGY IN CHILDREN
DOI:
https://doi.org/10.46793/PP240130003ZKeywords:
non-IgE-mediated food allergy, childrenAbstract
Nutrition allergy is unfavorable immune response to food proteins. Non-IgE-mediated gastrointestinal food allergy includes spectrum of disorders which are more uncommon that IgE- mediated food allergies. Their diagnosis is mainly done by clinical features cause the absence of specific biomarkers. Non-IgE-mediated food allergies include: food protein-induced enterocolitis sydrome (FPIES), food-protein induced allergic proctocolitis (FPIAP), food-protein induced allergic enteropathy (FPE), food protein induced dysmotility disorders (GERD) and mixed type diseases for examp. Eosinophilic esophagitis (EoE). In most cases non-IgE-mediated food allergy have a good prognosis and resolving during childhood.
References
Nomura I, Morita H, Hosokawa S et al. Four distinct subtypes of non-IgE-mediated gastrointestinal food allergies in neonates and infants, distinguished by their initial symptoms. J Allergy Immunol. 2011;127(3):685-688.e1-8. doi:10.1016/j.jaci.2011.01.019
Connors L, O Кeefe А, Rosenfield L, Kim H. Non-IgE-mediated food hypersesitivity. Allergy Asthma Clin Immunol. 2018;14(Suppl 2):56. doi:10.1186/s13223-018-0285-2
Sampson HA, Aceves S, Bock SA, et al. Food allergy: a practice parameter update-2014. J Allergy Clin Immunol. 2014;134(5):1016-1025.e43. doi10.1016/j.jaci.2014.05.013
Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel – PubMed. Available from: https://pubmed.nebi.nlm.nih.gov/21134576/. Accessed August 30, 2022
Caubet JC, Szajewska H, Shamir R, Nowak-Wegrzyn A. Non-IgE-mediated gastrointestinal food allergies in children. Pediatr Allergy Immunol. 2017;28(1):6-17. doi:10.1111/pai.12659
Morita H, Nomura I, Orihara K, et al. Antigen-specific T-cell responses in patients with non-IgE-mediated gastrointestinal food allergy are predominantly skewed to T(H)2. J Allergy Clin Immunol . 2013;131(2):590-2.el-6. doi:10.1016/j.jaci.2012.09.005
Ozen A, Gulcan EM, Ercan Saricoban H, Ozkan F, Cengizlier R. Food protein-induced non-immunoglobulin E-mediated allergic colitis in infants and older children: what cytokines are involved? Int Arch Allergy Immunol. 2015;168(1):61-68. doi: 10.1159/000441471
Nowak-Wegrzyn A, Katz Y, Mehr SS, Koletzko S. Non-IgE-mediated gastrointestinal food allergy. J Allergy Clin Immunol. 2015;135(5):1114-1124. doi:10.1016/j.jaci.2015.03.025
Pajanen L, Vaarala O, Karttunen R, Tuure T, Korpela R, Kokkonen J. Increased IFN-gamma secretion from duodenal biopsy samples in delayed-type cows milk allergy. Pediatr Allergy Immunol. 2005;16(5):439-444. doi:10.1111/j.1399-3038.2005.00312.x
Baker MG, Nowak-Wegrzyn A. Food protein-induced enterocolitis syndrom: epidemiology and comorbidites. Curr Opin Allergy Clin Immunol. 2020;20(2):168-174. doi:10.1097/aci.0000000000000615
Nowak-Wegrzyn A, Berin MC, Mehr S. Dood protein-induced enterocolitis syndrome. J Allergy Clin Immunol Pract. 2020;8(1):24-35. doi:10.1016/j.jaip.2019.08.020
Chung HL, Hwang JB, Park JJ, Kim SG. Expression of transforming growth factor beta 1, transforming growth factor type I and Iireceptors, and TNF-alpha in the mucosa of the small intestine in infants with food protein induced enterocolitis syndrome. J Allergy Clin Immunol.2002;109(1):150-154. doi:10/1067/mai.2002.120562
Berin MC, Lozano-Ojalvo D, Agashe C, Baker MG,Bird JA, Nowak-Wegrzyn A. Acute FPIES reactions are associated with an IL-17 inflammatory signature. J Allergy Clin Immunol. 2021;148(3):895-901.e6. doi:10.1016/j.jaci.2021.04.012
Mehr S, Frith K, Barnes EH, Campbell DE. Food protein-induced enterocolitis syndrome in Australia: population-based study, 2012-2014. J Allergy Clin Immunol. 2017;140(5):1323-1330. doi:10.1016/j.jaci.2017.03.027
Rosen R, Vandenplas Y, Singendonk M, Cabana M, Dilorenzo C, Gottrand F, et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American society for pediatric gastroenterology, hepatology and nutrition and the European society for pediatric gastroenterology, hepatology and nutrition. J Pediatr Gastro-enterol Nutr. 2018;66:516-54
Jensen ET, Kappelman MD, Kim HP, Ringel-Kulka T, Dellon ES. Early life exposures as risk factors for pediatric eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2013;57:67-71
Nowak-Wegrzyn A, Warren CM, Brown-Whitehorn T, Cianferoni A, Schults-Matney F, Gupta RS. Food protein-induced enterocolitis syndrome in the US population-based study. J Allergy Clin Immunol. 2019;144:1128-30
Martin VM, Virkud YV, Seay H, et al. Prospective assessment of pediatrician-diagnosed food protein-induced allergic proctocolitis by gross or occult blood. J Allergy Clin Immunol Pract. 2020;8(5):1692-1699/j.jaip.2019.12.029
Savilahti E, Food - Induced Malabsorption Syndromes. J Pediatr Gastroenterol Nutr. 2000;30(1):S61. doi:10.1097/00005176-200001001-00010
Hahn JW, Lee K, Shin JI, Cho SH, Turner S, Shin JU, et al. Global incidence and prevalence of osinophilic esophagitis, 1976-2022: a systematic review and meta-analysis. C Gastroenterol Hepatol . 2023. https://doi.org/10.1016/j.cgh.2023.06.005. Epub ahead of print
Mori F, Barni S, Cianferoni A, Pucci N, de Martino M, Novembre E. Cytokine expression in CD3+ cells in an infant with food proteininduced enterocolitis syndrome (FPIES): case report. Clin Dev Immunol. 2009;2009:679381. doi:10.1155/2009/679381
Feuille E, Nowak-Wegrzyn A. Food protein-induced enterocolitis syndrome, allergic proctocolitis, and enteropathy. Curr Allergy Asthma Rep. 2015;15(8):50
Carina V, Mario CV, David F. Tolerance development in non-IgE mediated food allergies: lessons from Brazil. Journal de Pediatria.2023;2:30. https://doi.org/10.1016/j.jped.2023 10.001
Chehade M, Aceves SS. Treatment of eosinophilic esophagitis: diet or medication? J Allergy Clin Immunol Pract. 2021;9(9):3249-3256. doi:10.1016/j.jaip.2021.07.029
Vasconcelos PD, Andrade AL, Sandy NS, Barreto JC, Gomez GS, Riccetto AG, et al. Outcomes and factors associated with tolerance in infants with non-IgE-mediated cows milk allergy with gastrointestinal manifestations. J Pediatr (Rio J). 2023. https://doi .org/10.1016/j.jped.2023.08.003. Epub ahead of print