SERUMSKE VREDNOSTI MOKRAĆNE KISELINE, TRIGLICERIDA I UKUPNOG BILIRUBINA SU POVEZANE SA INDEKSOM MASNE JETRE U ADOLESCENTNOJ POPULACIJI
Ključne reči:
dislipidemija, inflamacija, steatoza jetre, oksidativni stresApstrakt
Cilj: S obzirom na činjenicu da patofiziološki aspekt nealkoholne steatoze jetre nije u potpunosti razjašnjen, cilj studije je bio da se ispita povezanost dislipidemije, inflamacije i oksidativnog stresa sa Indeksom masne jetre (IMJ) u kohorti adolescentne populacije u Crnoj Gori.
Pacijenti i Metode: Ukupno 136 adolescenata je učestvovalo u studiji preseka. Antropometrijski i biohemijski marker su mereni. IMJ je izračunat. Povezanost biohemijskih parametara sa IMJ ispitana je univarijantnom i multivarijantnom ordinalnom regresionom analizom, sa tercilnim vrednostima IMJ kao zavisnom varijablom.
Rezultati: Prilagođene odds vrednosti za mokraćnu kiselinu (OR=2,641, P=0,007) i trigliceride (OR=5,275, P=0,008) pokazali su visoko značajnu pozitivnu povezanost sa IMJ. Suprotno tome, prilagođene odds vrednosti za bilirubin (OR=0,923, P=0,015) pokazale su značajnu negativnu povezanost sa IMJ. Premda su vrednosti C-reaktivnog proteina pozitivno korelirale sa IMJ u univarijantnoj (OR=1,962, P<0,001), isti je izgubio nezavisnu predikciju za IMJ u multivarijantnoj analizi (OR=1,442, P=0,130).
Zaključak: Serumske vrednosti mokraćne kiseline, triglicerida i ukupnog bilirubina su povezane sa IMJ u adolescenata. Longitudinalne studije su potrebne da potvrde uzročnu povezanost između pomenutih biomarkera i steatoze jetre, kao i da dalje ispitaju njihov dijagnostički potencijal za ovo oboljenje u mlađoj populaciji.
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